CHICAGO — A yearlong study offers rigorous new evidence against usingfor . In patients with stubborn or hip or knee arthritis, opioids worked no better than over-the-counter drugs or other nonopioids at reducing problems with walking or sleeping. And they provided slightly less pain relief.
Opioids tested included generic Vicodin, oxycodone or fentanyl patches although few patients needed the most potent opioids. Nonopioids included generic, and prescription pills for nerve or muscle pain. The study randomly assigned patients to take opioids or other painkillers. That’s the gold standard design for research.
If they don’t work better than less risky drugs, there’s no reason to use opioids given “their really nasty side effects — death and addiction,” said lead author Dr. Erin Krebs, a physician and researcher with the Minneapolis Veterans Affairs Health Care System.
The results likely will surprise many people “because opioids have this reputation as being really powerful painkillers, and that is not what we found,” Krebs said.
The study came out on the same day that the U.S. Centers for Disease Control (CDC) reported more troubling news about the scale of the current opioid epidemic. According to the CDC study, which examined data from 16 states, hospital emergency department visits for suspectedfrom July 2016 through September 2017. Some states saw increases of 70 or 80 percent or even more.
In a press briefing on Tuesday, CDC Acting Director Anne Schuchat, M.D., said the U.S. is seeing the highest drug overdose death rate ever recorded in the country.
The pain reduction study was published Tuesday in the Journal of the American Medical Association. Its findings echo the results of previous, less rigorous studies, providing more evidence to bolster guidelines against routine use of opioids for chronic pain.
About 42,000 drug overdose deaths in the U.S. in 2016 involved opioids, including, heroin and . Many people get hooked while taking opioids prescribed for injuries or other short-term pain and move on to cheaper, more accessible illicit drugs like heroin.
“I think people need to be aware that if they’re given an option for opioids, they should ask to try non-opioid options. It should be used in the lowest dose for the least amount of time possible, and that according to this study it was really not as effective,” CBS News medical contributor Dr. Tara Narula said on “CBS This Morning” Wednesday.
Krebs said the strongest evidence from other studies shows that physical therapy, exercise or rehabilitation therapy works best for chronic pain. And she said noted that there are a variety of nonopioid drugs to try if one type doesn’t work.
U.S.said opioids are not the preferred treatment for chronic pain, and they recommend non-drug treatment or nonopioid painkillers instead. Opioids should only be used if other methods don’t work for chronic pain, the guidelines recommend. Prescribing rates have declined slightly in recent years although they are still much higher than two decades ago.
“Doctors are more aware now,” Narula said, “and they are being more conscious about not prescribing.”
She added that patients also need to be aware of the risks and not seek prescription painkillers when other options are available. “A lot of this is education for patients, for families,” she said.
The study involved 234 patients from Minneapolis-area VA clinics who were assigned to use generic versions of opioids or nonopioids for a year. Follow-up ended in 2016.
“This is a very important study,” said Dr. David Reuben, geriatrics chief at UCLA’s medical school. “It will likely change the approach to managing long-term back, hip and knee pain.”
He noted one limitation — most study participants were men, but Krebs said the results in women studied were similar.
The study’s opioid patients started on relatively low daily doses of morphine, oxycodone or generic Vicodin. They switched to higher doses if needed or to long-acting opioids or fentanyl patches. The nonopioid group started on acetaminophen, ibuprofen or similar anti-inflammatory drugs. They also could switch to higher doses or prescription nonopioid pain pills. Few in either group used the strongest medicines.
Patients reported changes in function or pain on questionnaires. Function scores improved in each group by about two points on an 11-point scale, where higher scores meant worse function. Both groups started out with average pain and function scores of about 5.5 points.
Pain intensity dropped about two points in the nonopioid group and slightly less in the opioid patients.
Other research has shown that over-the-counter medicines can also work as well as opioids at treating short-term pain, including from broken bones, kidney stones or dental work.